In recent years, the effect of monetary policy on Macroeconomic Variables, and examining the role of central bank independence have been a challenging debate to which it has not produced any similar results in different studies. Accordingly, this study aims at examining the effect of the shock caused by monetary policy on macroeconomic variable considering the index of central bank independence. In this study, according to existing theoretical principles, we estimate Structural Vector Auto Regression (SVAR) which contain Monetary Policy Variables (legal reserve rate & interest rate), index of central bank independence, index of interest rate, inflation rate and oil price and use Impulse Response Function and Variance Decomposition for interpreting the results. In this order, we use Iran’s macroeconomic database from 1978 to 2016. This study came to a conclusion that the increase of legal reserve rate has, on the one side, meaningfully reduced economic growth rate, and, on the other side, central bank independence contributes to Variance Decomposition of inflation and economic growth rates. Additionally, central bank independence affects economic growth rate positively, and inflation rate negatively.